Dr Scott Rosa Research Paper

MELVILLE, NEW YORK, November 2, 2011 - FONAR Corporation (NASDAQ-FONR), The Inventor of MR Scanning™, reported today the cessation of symptoms in a 41-year-old female patient with multiple sclerosis following noninvasive treatment. The treatment was based on a recent major diagnostic breakthrough about the cause of multiple sclerosis achieved with the advanced FONAR UPRIGHT® MRI.

Misaligned cervical vertebrae in the patient (specifically, the vertebrae in the neck known as C-1, C-2, and C3) were causing blockage of the flow of cerebrospinal fluid. The malrotations of these vertebrae were initially discovered and visualized by the FONAR UPRIGHT® MRI, which showed that the vertebrae were rotated 5-6 degrees from their normal alignment.

When the vertebrae were successfully realigned, the patient’s symptoms subsided. The realignment was achieved by Dr. Scott Rosa, (Rock Hill, NY), using the noninvasive Atlas Orthogonal (AO) instrument, a device that can be used to tap the vertebrae back into normal alignment.

The patient is currently being maintained free of her MS symptoms, (vertigo and vomiting on recumbency) when recumbent, by weekly treatment with the AO instrument.

In the original study on which the diagnostic breakthrough was based, the Upright MRI further revealed that the cervical misalignments in the patient resulted in impairment of the flow of cerebrospinal fluid (CSF) on the posterior side of the spinal cord at the cervical joint between C-2 and C-3. When obstructed, the 500 cc of CSF generated daily within the ventricles of the brain cannot exit the ventricle and circulate normally down the spinal canal and return to the brain. The resulting buildup of CSF pressure gives rise to leakages of CSF fluid into the brain tissue surrounding the ventricles. The swelling in this MS patient (patient #8 of the recent study of CSF flows of 8 MS patients) was particularly pronounced in what are known as the posterior horns of the lateral ventricles. (Fig. 8, Damadian, R.V. and Chu, D., "The Possible Role of Cranio-Cervical Trauma and Abnormal CSF Hydrodynamics in the Genesis of Multiple Sclerosis" Physiol. Chem. and Physics and Medical NMR, September 20, 2011,41:1-17). The complete study in which the diagnostic breakthrough was reported can be viewed at www.fonar.com/pdf/PCP41_damadian.pdf.

The CSF leakages visualized were connected directly to the MS lesions visible in the MRI scans (Fig. 8). It became apparent to researcher Dr. Raymond Damadian that these leakages might be the cause of the MS patient's brain lesions.

Following treatment of the patient's cervical malrotations, which was performed by Dr. Scott Rosa (Rock Hill, NY), Upright MRI scans, as well as X-rays obtained by Dr. Rosa, showed that the cervical malrotations had been restored to normal.

At the same time, the patient reported that her severe vertigo and vomiting in the recumbent (lying down) position had ceased and that her stumbling from unequal leg length had disappeared.

When her MS symptoms had ceased, velocity maps (Fig. 16a & 16b) of the CSF flow through the spinal canal in the cervical area showed a striking reduction in the average velocity of the CSF fluid through the cervical area of the spinal cord, when compared to the CSF velocities before treatment (Fig. 16a). The flows are exhibited in graphs that record the velocity of the fluid in the flow pixels of the velocity maps. Notice the marked reduction in the number of high velocity CSF flow jets (red) after treatment, as compared with the number present prior to treatment. The high speed jets are caused by blockage of the flow of the CSF fluid, which compensates for the obstructions with increased flow rates in the unobstructed regions.

The reduction in the average velocity of CSF jets in the spinal canal corresponded with the patient's report that her MS symptoms had ceased. Concurrent with the CSF velocity measurements (Figs. 16a and 16b), a quantitative determination of the patient's CSF flow revealed that a 28.6% reduction in the patient's CSF pressure accompanied the cessation of her MS symptoms.

Detailed Caption for Figures 16a and 16b:

The misalignment of the cervical vertebrae (C-1) found by the FONAR UPRIGHT® MRI in the MS patient when she was imaged upright was successfully treated by Dr. Scott Rosa, using the Atlas Orthogonal (AO) instrumentation. She is the first of the patients in the MS study that has been treated thus far. The patient is currently being maintained free of MS symptoms (vertigo and vomiting on recumbency) by weekly treatment with the AO instrument. The patient's symptoms, severe vertigo accompanied by vomiting when lying down, and stumbling from unequal leg length, ceased as treatment was being administered. Figure 16a shows the velocity maps of the flow of cerebrospinal fluid (CSF) in the upright patient before treatment. The maps are visualized in 3D pixels, known as voxels. Figure 16b shows the pixel velocity maps of the same upright patient immediately following treatment. Figure 16b reveals an overall reduction in CSF velocity and, most significantly, the distinct reduction in the number of CSF flow jets (red), which are velocity spikes in CSF flow. In addition, average CSF velocity was reduced in the patient following treatment, as indicated in the maps by a reduction in average peak height. The overall flow of CSF was also more homogeneous after treatment, as indicated by fewer peak height variations. The CSF pixel velocities of Figure 16 were computed and mapped by FONAR scientists-engineers Michael Boitano and Bob Wolf. The CSF flow measurements obtained immediately following successful AO treatment of the patient also exhibited a 28.6% reduction of the patient's CSF pressure.

Citation:
Dolar, M.T., Haughton, V.M., Iskandar, B.J. and Quigley, M. (2004) Am. J. Neuroradiol., 25:142 reported analogous reductions in CSF pixel velocities in Chiari I patients after surgical decompression.

About FONAR

FONAR (NASDAQ:FONR), Melville, NY, The Inventor of MR Scanning™, was incorporated in 1978, and is the first, oldest and most experienced MRI company in the industry. FONAR introduced the world’s first commercial MRI in 1980, and went public in 1981. Since its inception, nearly 300 recumbent-OPEN MRIs and 150 UPRIGHT® Multi-Position™ MRI scanners have been installed worldwide. FONAR’s stellar product is the UPRIGHT® MRI (also known as the Stand-Up® MRI), the only whole-body MRI that performs Position™ imaging (pMRI™) and scans patients in numerous weight-bearing positions, i.e. standing, sitting, in flexion and extension, as well as the conventional lie-down position. The FONAR UPRIGHT® MRI often sees the patient’s problem that other scanners cannot because they are lie-down only. The patient-friendly UPRIGHT® MRI has a near-zero claustrophobic rejection rate by patients. As a FONAR customer states, “If the patient is claustrophobic in this scanner, they’ll be claustrophobic in my parking lot.” Approximately 85% of patients are scanned sitting while they watch a 42” flat screen TV. FONAR is headquartered on Long Island, New York.

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UPRIGHT® and STAND-UP® are registered trademarks and The Inventor of MR Scanning™, Full Range of Motion™, Multi-Position™, Upright Radiology™, The Proof is in the Picture™, True Flow™, pMRI™, Spondylography™, Dynamic™, Spondylometry™, CSP™, and Landscape™, are trademarks of FONAR Corporation.

This release may include forward-looking statements from the company that may or may not materialize. Additional information on factors that could potentially affect the company's financial results may be found in the company's filings with the Securities and Exchange Commission.

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Diagnostic Breakthrough in Multiple Sclerosis with FONAR UPRIGHT MRI Leads to
Noninvasive Treatment that Results in Symptoms of MS Patient Subsiding

A First-Hand Report – The Importance of Cerebrospinal Fluid (CSF) Flow in MS, and a Possible Chiropractic Approach to The Treatment of Neurodegenerative Disease

Recently, several studies have illuminated the important role that the proper flow of cerebrospinal fluid (CSF) through the brain and central nervous system plays in maintaining neurologic health, and also suggest that a disruption of CSF flow may play a part in a number of neurodegenerative diseases, MS included. Like CCSVI, which postulates that impeded bloodflow through the central nervous system plays a role in the development of Multiple Sclerosis, new research hints at a similar role for the flow of cerebrospinal fluid through the CNS.

Cerebrospinal fluid is a clear liquid that flows around the brain and spinal cord, and also fills natural voids in the anatomy of the brain, such as the ventricles and cisterns (the “empty” spaces in the brain as seen on MRI images). CSF serves several purposes. The brain and spinal cord are surrounded by CSF, the fluid in effect holding the brain in a state of suspension so that the weight of the organ is neutralized, keeping the lower part of the brain from suffering damage as a result of the total weight of the brain bearing down on it and pressing against the skull wall. In effect, the brain floats in a pool of CSF, which also acts as a cushion against sudden jolts or blows to the head. In instances where such trauma results in forces too great to be compensated for by the CSF, concussions can occur as a result of the brain crashing against the hard bone of the skull. Additionally, and no less importantly, CSF helps cleanse the brain of metabolic waste products, and also helps regulate the flow of blood through the central nervous system.

Most MS patients are familiar with CSF due to the ever popular and oh so pleasant procedure known as a lumbar puncture, or spinal tap. The stuff that the neuro draws out of your spine after sticking a spike into your back is CSF, which when analyzed can provide several indicators helpful in diagnosing the disease, such as oligoclonal bands, better known as O-bands. O-bands are an indicator of inflammation and immune activity going on within the central nervous system, an environment in which such activities are not welcomed. A vast majority of MS patients (upwards of 90%) have multiple O-bands, and the combination of CSF analysis and multiple lesions on MRI images are major components in completing a diagnosis of Multiple Sclerosis.

A number of recently published studies suggest that a breakdown in the natural flow of CSF can be quite detrimental to the central nervous system, and may be a driving force in the factors that culminate in neurodegenerative disease. One study (click here) discovered a previously unknown series of pathways that CSF follows throughout the central nervous system, providing new insights into the importance of CSF in the brain’s efforts to cleanse itself of potentially toxic metabolic waste products. Another study, done by Doctor Robert Zivadinov and the good people at BNAC, who are also doing extensive research into CCSVI, showed that CSF flow dynamics are altered in the brains of MS patients (click here).

Building upon the work of chiropractor Doctor Michael Flanagan, who has researched and written extensively on the role of CSF flow and neurodegenerative diseases (click here and here), another study, which used a specialized upright MRI device – known as a FONAR MRI – to scan MS patients, linked trauma to the upper neck and bottom of the skull to abnormal CSF flow and the eventual development of MS in study subjects (click here). This research, in turn, led to an ongoing investigation using FONAR MRI imaging in conjunction with a specialized chiropractic technique, known as Atlas Orthogonal, to demonstrate that not only is CSF flow abnormal in MS patients, but that this flow can be corrected by physically manipulating the Atlas bone, the uppermost cervical vertebra in the spinal cord. The bone gets its name because the weight of the entire head rests upon it, just as, in Greek mythology, the weight of the world rests on the shoulders of Atlas. This study is being headed up by chiropractor Doctor Scott Rosa and Doctor Raymond Damadian, the man who actually invented the MRI back in the 1970s.

The graphic below, which can be found at the information packed ATLANTOtec website (click here), nicely illustrates the detrimental impact a misaligned Atlas bone might have on blood vessels and nerves associated with the central nervous system:




In the above depiction, the yellow dot represents the vagus nerve, the blue dot the internal jugular vein, and the red dot the internal carotid artery. As the animation shows, a misaligned Atlas bone can put pressure on all three of these features, which, by appearances, one wouldn't imagine could do much good for the patient. Atlas Orthogonal chiropractors attempt to put the Atlas bone back into alignment using specialized techniques originated by Doctor Roy Sweat, which are taught at the Sweat Institute in Atlanta, Georgia (click here). The Atlas Orthogonal (AO) technique uses gentle pressure applied to the mastoid bone (behind the ear) to realign the Atlas bone, using a specialized table and an AO instrument carefully calibrated to each patient’s needs.

Since January, 2012, I’ve been taking part in the ongoing study being conducted by Doctor Rosa and Doctor Damadian, one of dozens of patients participating in the study. My involvement began with a trip up to Albany, New York, this past January, where I was scanned in an upright FONAR MRI that was outfitted with a prototype coil developed specifically to track CSF flow by Doctor Damadian, and which also utilized proprietary software to direct the scanning. After my initial scan, I was given an AO treatment, and then scanned again. Indeed, the differences between the two scans were rather dramatic. In my pretreatment scan, CSF flow was disrupted and seemed to double back and jet against my spinal cord directly at the spot where my one big lesion is  located. After the AO treatment, the scan showed a much more normal flow of CSF, resulting in a larger amount of fluid separating my brain from my skull base, and a more steady flow of CSF throughout my CNS.

It’s important to note that Doctor Rosa is using his own carefully developed derivation of the original Atlas Orthogonal therapy technique, using FONAR MRI imaging to calculate very specific parameters and angles for treatment (known as “vectors”). Therefore, his approach differs from that done by other AO practitioners, so much so that it is patent pending.

I’ve been receiving weekly follow-up treatment here in New York City by Doctor Scott Bender, who is working closely with Doctor Rosa on the study, and has been trained by Doctor Rosa on these specific techniques. This is not to say that the techniques practiced by other AO chiropractors are not potentially helpful, but the precise methodology Doctor Rosa uses is, at this time, unique. If study results warrant it, Doctor Rosa plans on training many additional practitioners in his approach, but until that time the exact techniques being used in this study are generally unavailable except from the few practitioners that have already been trained under Doctor Rosa’s guidance.

Although Doctor Rosa’s study is still underway, initial results appear to be promising. Some patients are reporting symptomatic improvements, but it is still too early to draw any conclusions. My own experience has thus far not been successful, as I have not (yet) derived any benefit from treatment. I’m a very poor example by which to judge, though, since my condition is extremely atypical, and, as I’ve previously written (click here), has defied all efforts at definitive diagnosis. Additionally, my body seems to have trouble holding the AO adjustment. Some patients report staying in alignment for many weeks after adjustment; I’m generally out of adjustment by the time I go back for my weekly visit to Doctor Bender.

Although provocative, the findings and hypotheses of Doctor Rosa and his associates are sure to be controversial, for many of the same reasons that CCSVI shook things up. Both theories fly in the face of traditional MS dogma, and offer explanations for neurodegenerative disease that differ greatly from those proffered by mainstream neurology. Multiple Sclerosis is nothing if not complicated, and its pathogenesis is almost certainly multifactorial. It’s doubtful that any one theory will prove to be THE key to solving the entire MS puzzle, but, given proper attention, some of these “radical” theories may have the potential to unlock the many mysteries held by MS, even if they do so tangentially. Investigations into the widely accepted autoimmune theory have yet to offer up anything approaching a cure, and the exploration of alternative theories, done responsibly, can only benefit patients as researchers broaden their horizons and begin understand MS as not strictly an immune modulated disease confined to the CNS, but a condition involving yet to be understood degenerative mechanisms with systemic implications as well.

As always, hope is on the horizon, and patience is the key. Unfortunately, for those of us suffering from a progressively crippling disease, patience comes at a very high price.

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